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464 0. 15:1 Age distribution Age (years) 1 year l4 years 59 years 1014 years 15 years Frequency () 7 35 25 20 13 Location Frequency () Head and neck (without orbit) Orbital Genitourinary Extremities Trunk Retroperitoneal Perineal and anal Others 26 9 22 18 7 7 2 9 INDEX ACI rat model, for animal prostate can- cer, 36-37 Acidic mucin, 12 Adenomatous polyposis coli (APC) gene, 86-87, 93-94, 102 Adjuvant therapy (see Neoadjuvant hormonal therapy) Adrenal-suppressive agent therapy, 240, 244-245 Aminoglutethimide, 244 Androgen receptor (AR) alterations, 173-177 Androgens ablation therapy, 125-128, 129, 173-174 angiogenic factors, 141-142 animal studies of, 37, 39 anti-androgen administration ther- apy, 242-243 emixsion withdrawal therapy, 241-242, 244 blockade therapy, 28, 195 neoadjuvant hormonal therapy, 216- 218 neoadjuvant hormonal therapy and, 221-224 Angiogenesis 12(S) HETE and, 143-145 activation by genetic changes, 147 angiogenic switch, 145 eicosanoid regulation, 147-148 inhibitors, 142-143, 148 principles of, 140 as prognostic and diagnostic marker, 148 regulation by steroid hormones, 146-147 regulator emisxion, 146 therapies, 148-149 Angiostatin, as angiogenesis inhibitor, 142-143, 149 Anoikis, defined, 133 Anti-angiogenesis therapy, 142-143, 250 Apoptosis androgen ablation and, 125-128, 216,222 characterization of, 123-124 chemotherapeutic drugs and, 128 interleukin-6, 133 modulation of signal transducers, 131-133 oncoprotein manipulation, 129-130 regulating factors, 3, 124, 165 role in prostate cancer, 125-127 Atypical small acinar proliferations, 1415 257 88 STEVE A.
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