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10 !0. Based on Work by Galileo. Superior surgical approach, to proximal humerus, 15261528. Drug Effect Drugs Change in thyroid hormone synthesis Inhibition of TRH or TSH secretion without induction of hypothyroidism Dopamine, levodopa, corticosteroids, somatostatin Inhibition of thyroid hormone synthesis or release with the induction of hypothyroidism (or occasionally hyperthyroidism) Iodides (including amiodarone), lithium, aminoglutethimide Alteration of thyroid hormone transport and serum total T3 and T4 levels, but usually no modification of FT4 or TSH Increased TBG Estrogens, tamoxifen, heroin, methadone, mitotane Decreased TBG Androgens, glucocorticoids Displacement of T3 and T4 from TBG with transient hyperthyroxinemia Salicylates, fenclofenac, mefenamic acid, furosemide Alteration of T4 and T3 metabolism with modified serum T3 and T4 levels but not FT4 or TSH levels Induction of increased hepatic enzyme activity Inhibition of 5'-deiodinase with decreased T3, Phenytoin, carbamazepine, phenobarbital, rifampin, rifabutin Iopanoic acid, ipodate, amiodarone, -blockers, increased rT3 corticosteroids, propylthiouracil Other interactions Interference with T4 absorption Cholestyramine, colestipol, aluminum hydroxide, sucralfate, reloxifene, ferrous sulfate, some calcium preparations, bran Induction of autoimmune thyroid disease with hypothyroidism or hyperthyroidism Interferon- ,interleukin-2 682 Appendix D Programming Precepts, Pointers, and Pitfalls 6.
Current concepts: immunology. Journal of Zoology, London, 213, 51 ± 61. 1 The Rauch-Tung-Streibel fixed-interval smoother.
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